Acetyl chloride → 3-{5-(Acetylamino)-6-[(2,2-dimethyl-propyl)-methyl-amino]-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide

HRID 852037Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 852037
[NH2:1][C:2]1[C:3]([NH:15][C:16]2[CH:17]=[C:18]([CH:23]=[CH:24][C:25]=2[CH3:26])[C:19]([NH:21][CH3:22])=[O:20])=[N:4][CH:5]=[N:6][C:7]=1[N:8]([CH2:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH3:9].[C:27](Cl)(=[O:29])[CH3:28].C(N(CC)CC)C>C(Cl)Cl>[C:27]([NH:1][C:2]1[C:3]([NH:15][C:16]2[CH:17]=[C:18]([CH:23]=[CH:24][C:25]=2[CH3:26])[C:19]([NH:21][CH3:22])=[O:20])=[N:4][CH:5]=[N:6][C:7]=1[N:8]([CH2:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH3:9])(=[O:29])[CH3:28]

Komponenten

5

Edukt 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 99467743-{5-Amino-6-[(2,2-dimethyl-propyl)-methyl-amino]-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide

Produkt 1

HCID 102943103-{5-(Acetylamino)-6-[(2,2-dimethyl-propyl)-methyl-amino]-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3-{5-Amino-6-[(2,2-dimethyl-propyl)-methyl-amino]-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide (16 mg), acetyl chloride (3.5 mg), triethylamine (0.02 ml) were stirred in methylene chloride (0.2 mL) at room temperature for overnight. The product (2.8 mg) was purified by preparative thin layer chromatography. MS (m/z): 399 (M+H).

Aufarbeitung

  1. customThe product (2.8 mg) was purified by preparative thin layer chromatography

Quellen und Nachweise

ORD-Eintrag
ord-2913e7c25c2549e6b486bc59dc6c1694
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07253174B2

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