(2-(Benzyloxy)pyridin-4-yl)methanol → 2-(Benzyloxy)isonicotinaldehyde

HRID 852068Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 852068
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH2:15][OH:16])[CH:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH:12]=[CH:11][N:10]=1)[CH:15]=[O:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 1

HCID 16096699(2-(Benzyloxy)pyridin-4-yl)methanol

Produkt 1

HCID 229262712-(Benzyloxy)isonicotinaldehydeAusbeute 89,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A suspension of [2-(benzyloxy)-4-pyridyl]methanol (6.0 g) and activated manganese dioxide (30 g) in chloroform (180 mL) was heated under reflux for 2.5 hours. After the reaction solution was allowed to cool to room temperature, the manganese dioxide was filtered off and washed with ethyl acetate. The filtrate was concentrated to give the title compound as a pale brown oil (5.34 g).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 2.5 hours
  3. filtrationthe manganese dioxide was filtered off
  4. washwashed with ethyl acetate
  5. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-17676fa1028d4f38b483ccd90421ca33
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07253178B2

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