Boron tribromide → 3-(6-Fluoro-benzo[d]isoxazol-3-yl)-phenol
Reaktionsgleichung
[F:1][C:2]1[CH:18]=[CH:17][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([O:15]C)[CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1.B(Br)(Br)Br>ClCCl>[F:1][C:2]1[CH:18]=[CH:17][C:5]2[C:6]([C:9]3[CH:10]=[C:11]([OH:15])[CH:12]=[CH:13][CH:14]=3)=[N:7][O:8][C:4]=2[CH:3]=1Komponenten
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
Combine 6-fluoro-3-(3-methoxy-phenyl)-benzo[d]isoxazole (30 g, 0.123 mol) and dichloromethane (anhydrous, 360 mL) under nitrogen atmosphere and cool (0° C.). Slowly add 1.0 M solution of boron tribromide in dichloromethane (370 mL, 0.370 mol) over 1 hour and stir at 0° C. for 3 hours. TLC indicates that all starting material is consumed. Quench the reaction mixture with 150 mL methanol, concentrate and azeotrope off the boron tribromide two more times with methanol. Dissolve the material in ethyl acetate, wash with K2CO3, saturated sodium chloride, dry (MgSO4) and concentrate. Triturate in heptane:dichloromethane (9:1), filter and wash with heptane and dry in the oven to give the title compound (26.93 g, 95% Yield). NMR and microanalysis (C, H, N) are consistent with the final, desired compound. mp=144-145° C.
Aufarbeitung
- customis consumed
- customQuench the reaction mixture with 150 mL methanol
- concentrationconcentrate
- dissolutionDissolve the material in ethyl acetate
- washwash with K2CO3, saturated sodium chloride
- dry with materialdry (MgSO4)
- concentrationconcentrate
- customTriturate in heptane:dichloromethane (9:1)
- filtrationfilter
- washwash with heptane
- customdry in the oven
Quellen und Nachweise
- ORD-Eintrag
- ord-0134904e1d2f49d2a542ae89e731dab2
- Quelldatensatz
- uspto-grants-2007_08
- Patentnummer
- US07253165B2
Notizen zur Reaktion
Wird geladen…