HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dimethylformamide → (S)-1-(3,4-dihydro-1H-isoquinolin-2-yl)-3-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | (S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole | HCID 11254641 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Lösungsmittel | 1,2,3,4-Tetrahydroisoquinoline | HCID 7046 | — |
| Produkt | (S)-1-(3,4-dihydro-1H-isoquinolin-2-yl)-3-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol | HCID 9823314 | — |
Reaktionsschritte
The title compound is prepared from a mixture of (S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and 1,2,3,4-tetrahydroisoquinoline in ethanol essentially as described above in Example 21. Purity by LC/MS=98%, [M+H]+=419.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07253165B2 |
| Quelldatensatz | uspto-grants-2007_08 |
| ORD ID | ord-048dda65d4d14529a240203862be4073 |
| Quellennotiz | uspto-grants-2007_08 |