6-[2-(4-Chlorophenyl)-1,3-dioxolan-2-yl]-4-(3-methoxyphenyl)-2(1h)-quinolinone → 6-(4-Chlorobenzoyl)-4-(3-methoxyphenyl)-2(1h)-quinolinone

HRID 852273Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 852273
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[NH:19][C:18](=[O:23])[CH:17]=[C:16]4[C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=3)OCC[O:9]2)=[CH:4][CH:3]=1>Cl.CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[NH:19][C:18](=[O:23])[CH:17]=[C:16]3[C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=2)=[O:9])=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 227143486-[2-(4-Chlorophenyl)-1,3-dioxolan-2-yl]-4-(3-methoxyphenyl)-2(1h)-quinolinone

Produkt 1

HCID 227143706-(4-Chlorobenzoyl)-4-(3-methoxyphenyl)-2(1h)-quinolinoneAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of interm. (5-e) (43 g) in HCl (3N, 400 ml) and methanol (150 ml) was stirred and refluxed overnight. The mixture was cooled and filtered off. The precipitate was washed with water and diethyl ether and dried. The product was used without further purification, yielding 27 g (94%) of 6-(4-chlorobenzoyl)-4-(3-methoxyphenyl)-2(1H)-quinolinone (interm. 5-f).

Aufarbeitung

  1. additionA mixture of interm
  2. temperaturerefluxed overnight
  3. temperatureThe mixture was cooled
  4. filtrationfiltered off
  5. washThe precipitate was washed with water and diethyl ether
  6. customdried
  7. customThe product was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-4d39bd787adb403686aad58177d1c467
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07253183B2

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