(4-Acetylsulfanyl-2-methyl-phenoxy)-acetic acid tert-butyl ester → {2-Methyl-4-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynylsulfanyl]-phenoxy}-acetic acid tert-butyl ester

HRID 852363

Reaktionsgleichung

Reaktionsgleichung von HRID 852363
[C:1]([O:5][C:6](=[O:20])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([S:15][C:16](=O)[CH3:17])=[CH:11][C:10]=1[CH3:19])([CH3:4])([CH3:3])[CH3:2].[F:21][C:22]([F:41])([F:40])[O:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]#[C:31][CH2:32]CCOS(C)(=O)=O)=[CH:26][CH:25]=1>>[C:1]([O:5][C:6](=[O:20])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([S:15][CH2:16][CH2:17][CH2:32][C:31]#[C:30][C:27]2[CH:26]=[CH:25][C:24]([O:23][C:22]([F:21])([F:40])[F:41])=[CH:29][CH:28]=2)=[CH:11][C:10]=1[CH3:19])([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 11572955(4-Acetylsulfanyl-2-methyl-phenoxy)-acetic acid tert-butyl esterHCID 11616756Methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl ester

Produkt 1

HCID 11518617{2-Methyl-4-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynylsulfanyl]-phenoxy}-acetic acid tert-butyl ester

Versuchsvorschrift

In analogy to the procedure described in example 1D], (4-acetylsulfanyl-2-methyl-phenoxy)-acetic acid tert-butyl ester (example 4A]) was reacted with methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl ester (example 1G]) to give the title compound a light yellow oil.

Quellen und Nachweise

ORD-Eintrag
ord-0aee6a9c83e7475b897de2df4e99aeb0
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07253192B2

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