(E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-one → 4-((4-(2-(Tert-butoxycarbonylamino)-4-methylthiazol-5-yl)-pyrimidin-2-ylamino)methyl)benzoic acid

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	(E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-one	HCID 5825354	—
Edukt	(E)-1-[2-(Boc-Amino-)-4-methylthiazol-5-yl]-3-(dimethylamino)prop-2-en-1-one	HCID 58930506	—
Edukt	4-[(4-Pyrazin-2-yl-pyrimidin-2-ylamino)-methyl]-benzoic acid	HCID 66622167	—
Produkt	4-((4-(2-(Tert-butoxycarbonylamino)-4-methylthiazol-5-yl)-pyrimidin-2-ylamino)methyl)benzoic acid	HCID 58930474	18%

Reaktionsschritte

Following the procedure described for the synthesis of the acid 25a (scheme 6, step 3) but substituting enamino ketone 23a for the enamino ketone 338, title compound was obtained in 18% yield and was used for the next steps without further purification. MS (m/z): 441.50 (calc) 442.3 (MH+) (found).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07253204B2
Quelldatensatz	uspto-grants-2007_08
ORD ID	ord-e9a5801045ab4a7dadb599f28f457a1c
Quellennotiz	uspto-grants-2007_08