4-Nitrophenol → 6-Cyano-7-(2-methoxyethoxy)-4-(4-nitrophenoxy)quinoline

HRID 853214

Reaktionsgleichung

Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:15][CH2:16][O:17][CH3:18])=[C:9]([C:12]#[N:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[N+:19]([C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)([O-:21])=[O:20].N1C(C)=CC=CC=1C>C(OCC)(=O)C>[C:12]([C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH2:15][CH2:16][O:17][CH3:18])[N:5]=[CH:4][CH:3]=[C:2]2[O:28][C:25]1[CH:26]=[CH:27][C:22]([N+:19]([O-:21])=[O:20])=[CH:23][CH:24]=1)#[N:13]

Komponenten

Reaktionsbedingungen

Temperatur: 155 °C

Versuchsvorschrift

A mixture of 4-chloro-6-cyano-7-(2-methoxyethoxy)quinoline (3 g), 4-nitrophenol (3.17 g) and 2,6-lutidine (2.7 ml) was heated and stirred in an oil bath at 155° C. for 1.5 hours. After completion of the reaction, ethyl acetate was added, and the precipitated solid was filtered out. The solid was washed with 1N sodium hydroxide water and then with water and dried to obtain 1.8 g of the title compound.

Aufarbeitung

temperaturewas heated
additionwas added
filtrationthe precipitated solid was filtered out
washThe solid was washed with 1N sodium hydroxide water
dry with materialwith water and dried

Quellen und Nachweise

ORD-Eintrag: ord-5d00d7a841b449c38a8f5e7a2f2bb764
Quelldatensatz: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07253286B2

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