Aluminium lithium hydride → 2-[2-(6-Chloro-pyridin-3-yl)-5-methyl-oxazol-4-yl]-ethanol
Reaktionsgleichung
C[O:2][C:3](=O)[CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:12]=[N:13][C:14]([Cl:17])=[CH:15][CH:16]=2)[O:8][C:9]=1[CH3:10].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[Cl:17][C:14]1[N:13]=[CH:12][C:11]([C:7]2[O:8][C:9]([CH3:10])=[C:5]([CH2:4][CH2:3][OH:2])[N:6]=2)=[CH:16][CH:15]=1Komponenten
4
Versuchsvorschrift
To a solution of [2-(6-Chloro-pyridin-3-yl)-5-methyl-oxazol-4-yl]-acetic acid methyl ester (4.0 g, 15 mmol) from step B in THF (50 mL) is added a solution of lithium aluminum hydride in THF (1.0 M, 12.5 mL, 12.5 mmol) at 0° C. After 1 hr, the reaction is quenched by water and sodium hydroxide, filtered, concentrated. The crude material is used for the next step.