Triethylamine → Ethyl 4-methyl-2-(4-methylbenzoylamino)-3-oxopentanoate

HRID 854615Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 854615
Cl.[NH2:2][CH:3]([C:9](=[O:13])[CH:10]([CH3:12])[CH3:11])[C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH3:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1.C(N(CC)CC)C>ClCCl>[CH3:11][CH:10]([CH3:12])[C:9](=[O:13])[CH:3]([NH:2][C:19](=[O:20])[C:18]1[CH:22]=[CH:23][C:15]([CH3:14])=[CH:16][CH:17]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 134054-Methylbenzoyl ChlorideHCID 57434496Ethyl 2-amino-4-methyl-3-oxopentanoate hydrochloride

Produkt 1

HCID 57434497Ethyl 4-methyl-2-(4-methylbenzoylamino)-3-oxopentanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

10 g of ethyl 2-amino-4-methyl-3-oxopentanoate hydrochloride and 7.4 g of 4-methylbenzoyl chloride are dissolved in 250 ml of dichloromethane, and 13.3 ml of triethylamine are slowly added dropwise at 0° C. The mixture is stirred at room temperature for one hour and then washed with water, the organic phase is separated off and dried over MgSO4 and the solvent is then removed under reduced pressure. This gives 13 g of ethyl 4-methyl-2-(4-methylbenzoylamino)-3-oxopentanoate as an oil. C16H21NO4 (291.35), MS (ESI)=292 (M+H+).

Aufarbeitung

  1. washwashed with water
  2. customthe organic phase is separated off
  3. dry with materialdried over MgSO4
  4. customthe solvent is then removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ee3f77be50a5460287543f160d3c0990
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07259177B2

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