Methyl iodide → Methyl 1-(1-methylethyl)-6-nitro-1H-indazole-4-carboxylate

HRID 85510Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 85510
[H-].[Na+].[N+:3]([C:6]1[CH:7]=[C:8]([C:15]([O:17][CH3:18])=[O:16])[C:9]2[CH:10]=[N:11][NH:12][C:13]=2[CH:14]=1)([O-:5])=[O:4].Br[CH:20]([CH3:22])[CH3:21].IC>CS(C)=O.CN(C)C=O>[CH3:21][CH:20]([N:12]1[C:13]2[CH:14]=[C:6]([N+:3]([O-:5])=[O:4])[CH:7]=[C:8]([C:15]([O:17][CH3:18])=[O:16])[C:9]=2[CH:10]=[N:11]1)[CH3:22]

Komponenten

7

Edukt 4

HCID 6328Methyl iodideHCID 63582-BromopropaneHCID 24758Sodium hydrideHCID 24728069Methyl 6-nitro-1H-indazole-4-carboxylate

Produkt 1

HCID 67468642Methyl 1-(1-methylethyl)-6-nitro-1H-indazole-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Sodium hydride (1.142 g, 45.2 mmol) was added to N,N-Dimethylformamide (DMF) (100 mL) which was cooled in a ice water bath. A DMSO solution (20 mL) of methyl 6-nitro-1H-indazole-4-carboxylate (5 g, 22.61 mmol) was then added dropwise. After 15 minutes was added 2-bromopropane (4.25 mL, 45.2 mmol) dropwise and the contents were stirred at room temperature for 16 hours. Next added iodomethane (2.83 mL, 45.2 mmol) and let stir at room temperature for 3 hours followed by heating at 50° C. for 3 hours. The solvent was removed in vacuo. The residue was purified via silica gel chromatography (eluent: 0% to 25% EtOAc:Hex) to afford the product as 1.39 g (23%). 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 4.07 (s, 3H), 8.61-8.63 (m, 1H), 8.64 (s, 1H), 8.73 (d, J=2.02 Hz, 1H); LCMS(ES) [M+H]+264.0

Aufarbeitung

  1. temperaturewas cooled in a ice water bath
  2. stirringlet stir at room temperature for 3 hours
  3. temperatureby heating at 50° C. for 3 hours
  4. customThe solvent was removed in vacuo
  5. customThe residue was purified via silica gel chromatography (eluent: 0% to 25% EtOAc:Hex)
  6. customto afford the product as 1.39 g (23%)

Quellen und Nachweise

ORD-Eintrag
ord-33c9fc963a27425ca2ee9abd712cb6b0
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846935B2

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