Dichloromethane → HCID 86603108, Verbindung

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Dichloromethane	HCID 6344	—
Edukt	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Edukt	6-fluoro-1H-indole-7-carboxylic Acid	HCID 11708161	—
Edukt	(4-Tert-butylbenzyl)-[2-(4-chlorophenyl)-ethyl]-amine	HCID 29792506	—
Produkt	HCID 86603108	HCID 86603108	40%

Reaktionsschritte

To a solution of 59 mg (0.33 mmol) of 6-fluoro-1H-indole-7-carboxylic acid and 91 mg (0.3 mmol) of (4-tert-butyl-benzyl)-[2-(4-chloro-phenyl)-ethyl]-amine in 3 ml DCM 63 mg (0.33 mmol) of EDC.HCl were added and the reaction mixture was stirred over night at rt. The product was purified by column chromatography (20 g silica gel; heptane/EtOAc 4:1) to yield 55 mg (40%) product as a white solid. MS (ISP) 463.4 (M+H)+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07259183B2
Quelldatensatz	uspto-grants-2007_08
ORD ID	ord-d4c7554bdca1475bb77bdb45e45d6ca8
Quellennotiz	uspto-grants-2007_08