Methylamine → Methyl((1-methylpiperidin-3-yl)methyl)amine

A solution of 3-(chloromethyl)-1-methylpiperidine (9.2 g, 50 mmol) (U.S. Pat. No. 6,184,338, example 5) and 33% methylamine in ethanol (60 mL) in ethanol (30 mL) was heated in a sealed vessel at 100° C. for 17 hours. The reaction mixture was concentrated in vacuo and diluted with water before being extracted into dichloromethane and dried over magnesium sulphate. The reaction mixture was filtered and concentrated in vacuo to yield the title product, 8.2 g.

1. concentrationThe reaction mixture was concentrated in vacuo
2. additiondiluted with water
3. extractionbefore being extracted into dichloromethane
4. dry with materialdried over magnesium sulphate
5. filtrationThe reaction mixture was filtered
6. concentrationconcentrated in vacuo

ORD-Eintrag

ord-38f5bbda7a9440e8b4853f15c4b7d2a2

Quelldatensatz

uspto-grants-2007_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07262192B2