Hydrochloric Acid → Ethyl 4-bromobenzimidate hydrochloride

HRID 855800Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 855800
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[ClH:10].[CH2:11]([OH:13])[CH3:12]>>[ClH:10].[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6](=[NH:7])[O:13][CH2:11][CH3:12])=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 12162Benzonitrile, 4-bromo-

Produkt 1

HCID 19017302Ethyl 4-bromobenzimidate hydrochloride

Versuchsvorschrift

A cold solution (0° C.) of 4-bromobenzonitrile (1 g, 5.5 mmol) in ethanol (25 mL) was saturated with dry HCl(g). The mixture was then stirred at room temperature for 18 hours, after which FT-IR showed complete disappearance of the nitrile. The solution was concentrated to dryness, and further dried in vacuo. The ethyl 4-bromobenzimidate hydrochloride thus obtained was used in the synthesis of compounds 145, 146, 150, and 151.

Aufarbeitung

  1. concentrationThe solution was concentrated to dryness
  2. customfurther dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c256b8f28f7c482faf2a12a7ce338871
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07262223B2

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