2-Pentanone, 5-(acetyloxy)- → 4-Methyl-4-pentenyl acetate

HRID 856115

Reaktionsgleichung

Reaktionsgleichung von HRID 856115
[CH3:1][C:2]([CH3:5])([O-])[CH3:3].[K+].[C:7]([O:10][CH2:11][CH2:12]CC(=O)C)(=[O:9])[CH3:8]>[Br-].C[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C1COCC1>[C:7]([O:10][CH2:11][CH2:12][CH2:1][C:2]([CH3:5])=[CH2:3])(=[O:9])[CH3:8]

Komponenten

5

Edukt 2

HCID 212582-Pentanone, 5-(acetyloxy)-HCID 23665647Potassium tert-butoxide

Produkt 1

HCID 122313854-Methyl-4-pentenyl acetateAusbeute 60,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 74505Methyltriphenyliphosphonium bromideKatalysatorHCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

Potassium tert-butoxide (9.4 g, 84 mmol) was added to a mixture of methyltriphenylphosphonium bromide (30 g, 84 mmol) in THF (300 ml), and the mixture was stirred at room temperature for 40 minutes. To the mixture a solution of 4-oxopentyl acetate (9.9 g, 68.8 mmol) in THF (30 ml) was gradually added dropwise while cooling in an ice-bath, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was poured into ice water, and extracted with diethyl ether twice. The extracts were combined, washed with brine, and dried over magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane/ethyl acetate=4/1) to afford 4-methyl-4-pentenyl acetate (5.9 g, yield 60.4%) as a colorless oil.

Aufarbeitung

  1. temperaturewhile cooling in an ice-bath
  2. stirringthe mixture was stirred at room temperature for 2 hours
  3. extractionextracted with diethyl ether twice
  4. washwashed with brine
  5. dry with materialdried over magnesium sulfate
  6. filtrationAfter filtration
  7. concentrationthe filtrate was concentrated under reduced pressure
  8. customThe residue was purified by silica gel column chromatography (n-hexane/ethyl acetate=4/1)

Quellen und Nachweise

ORD-Eintrag
ord-20fd1cb0da5b437da272849fb0179b44
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07262212B2

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