Thionyl Chloride → HCID 22938786, Verbindung

HRID 856644Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 856644
[CH2:1]([N:3]1[CH:7]=[N:6][N:5]=[C:4]1[CH2:8]O)[CH3:2].S(Cl)([Cl:12])=O>>[ClH:12].[Cl:12][CH2:8][C:4]1[N:3]([CH2:1][CH3:2])[CH:7]=[N:6][N:5]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 22938611(4-ethyl-4H-1,2,4-triazol-3-yl)methanol

Produkt 1

HCID 22938786HCID 22938786, Verbindung

Versuchsvorschrift

To 4-ethyl-3-hydroxymethyl-4H-1,2,4-triazole (4.6 g), thionyl chloride (36 ml) was slowly added at 0° C. The mixture was heated to reflux for 1 hour, and concentrated under reduced pressure. To the residue was added ethyl acetate and ethanol, and the precipitated crystals were collected by filtration. The crystals were washed with ethyl acetate, to give 3-chloromethyl-4-ethyl-4H-1,2,4-triazole hydrochloride (4.22 g) as orange crystals.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 1 hour
  3. concentrationconcentrated under reduced pressure
  4. additionTo the residue was added ethyl acetate and ethanol
  5. filtrationthe precipitated crystals were collected by filtration
  6. washThe crystals were washed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-72fe571441664a4e9be409866d900805
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07262185B2

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