Thionyl Chloride → HCID 22938853, Verbindung

HRID 856756Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 856756
[CH:1]1([CH2:4][N:5]2[CH:9]=[CH:8][N:7]=[C:6]2[CH2:10]O)[CH2:3][CH2:2]1.S(Cl)([Cl:14])=O>>[ClH:14].[Cl:14][CH2:10][C:6]1[N:5]([CH2:4][CH:1]2[CH2:3][CH2:2]2)[CH:9]=[CH:8][N:7]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 229387391-Cyclopropylmethyl-2-hydroxymethylimidazole

Produkt 1

HCID 22938853HCID 22938853, Verbindung

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To 1-cyclopropylmethyl-2-hydroxymethylimidazole (2.50 g) was added thionyl chloride (25 ml) at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature, the solvent was distilled off under reduced pressure and the obtained solid was washed with ethyl acetate, to give 2-chloromethyl-1-cyclopropylmethylimidazole hydrochloride. (2.96 g) as brown crystals.

Aufarbeitung

  1. customto be at room temperature
  2. distillationthe solvent was distilled off under reduced pressure
  3. washthe obtained solid was washed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-813269d41bda4f7791b86ff74507be63
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07262185B2

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