Triphenylphosphine → Chroman-7-ol

HRID 856940

Reaktionsgleichung

Reaktionsgleichung von HRID 856940
O[CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][C:6]=1[OH:12].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1CCN(C(N=NC(N2CCCCC2)=O)=O)CC1>C1COCC1>[O:12]1[C:6]2[C:5](=[CH:10][CH:9]=[C:8]([OH:11])[CH:7]=2)[CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 11776TriphenylphosphineHCID 730421,1'-(Azodicarbonyl)dipiperidineHCID 129584034-(3-Hydroxypropyl)benzene-1,3-diol

Produkt 1

HCID 12236542Chroman-7-olAusbeute 66,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a stirred solution of 4-(3-Hydroxy-propyl)-benzene-1,3-diol (3.05 g, 18.1 mmol, from Step 1) in anhydrous THF (50 mL) were added Ph3P (7.13 g, 27.2 mmol, 1.5 eq) and ADDP (6.86 g, 27.2 mmol, 1.5 eq) under argon. The mixture was stirred at rt for 17 h. The white solid was filtered off and the solvent was removed from the filtrate. The residue was purified on silica gel (flash column chromatography) eluting with 5% ethyl acetate-hexane followed by 20% ethyl acetate-hexane to provide the desired product as white solid (1.80 g, 60.5%). 1H-NMR (CD3CN) δ 6.87 (d, 1H), 6.70 (broad, s, 1H, OH), 6.31 (dd, J=2.4, 8.2 Hz, 1H), 6.20 (d, 1H), 4.12 (t, 2H), 2.69 (t, 2H), 1.95 (m, 2H).

Aufarbeitung

  1. filtrationThe white solid was filtered off
  2. customthe solvent was removed from the filtrate
  3. customThe residue was purified on silica gel (flash column chromatography)
  4. washeluting with 5% ethyl acetate-hexane

Quellen und Nachweise

ORD-Eintrag
ord-66eb7b3901e741bd95fa9fb2d63abc81
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07144885B2

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