Hydrochloric Acid → {1-[3-(1-Amino-ethyl)-phenyl]-pyrrolidin-3-yl}-dimethyl-amine

HRID 857020Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 857020
C(OC(=O)[NH:7][CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N:16]2[CH2:20][CH2:19][CH:18]([N:21]([CH3:23])[CH3:22])[CH2:17]2)[CH:11]=1)[CH3:9])(C)(C)C.Cl>C(OCC)(=O)C>[NH2:7][CH:8]([C:10]1[CH:11]=[C:12]([N:16]2[CH2:20][CH2:19][CH:18]([N:21]([CH3:22])[CH3:23])[CH2:17]2)[CH:13]=[CH:14][CH:15]=1)[CH3:9]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 69588726{1-[3-(3-Dimethylamino-pyrrolidin-1-yl)-phenyl]-ethyl}-carbamic acid tert-butyl ester

Produkt 1

HCID 21864685{1-[3-(1-Amino-ethyl)-phenyl]-pyrrolidin-3-yl}-dimethyl-amineAusbeute 99,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of {1-[3-(3-dimethylamino-pyrrolidin-1-yl)-phenyl]-ethyl}-carbamic acid tert-butyl ester (1.8 g) and 4 ml of 4 N HCl in ethyl acetate (10 mL) at 50° C. was stirred for 2 h. After concentration, the residue was neutralized with 10 N NaOH and extracted with methylene chloride. The organic layer was washed with brine, dried over Na2SO4, and concentrated to give the crude product (1.25 g) as an oil.

Aufarbeitung

  1. concentrationAfter concentration
  2. extractionextracted with methylene chloride
  3. washThe organic layer was washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-7d1febe87c3e4c24a430ef9f115c547a
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07144881B2

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