Hydrochloric Acid → (R)-2-Amino-2-(naphthalen-2-yl)ethanol hydrochloride

HRID 857026Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 857026
C(OC(=O)[NH:7][C@H:8]([C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=1)[CH2:9][OH:10])(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[NH2:7][C@H:8]([C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=1)[CH2:9][OH:10]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 57419701(R)-(2-Hydroxy-1-naphthalen-2-yl-ethyl)-carbamic acid tert-butyl ester

Produkt 1

HCID 57462036(R)-2-Amino-2-(naphthalen-2-yl)ethanol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

(R)-(2-Hydroxy-1-naphthalen-2-yl-ethyl)-carbamic acid tert-butyl ester (2.5 g) and 9 mL of 4 N HCl in ethyl acetate at 50° C. was stirred for 2 h. After concentration, the residue was neutralized with 10 N NaOH and extracted with methylene chloride. The organic layer was washed with brine, dried over Na2SO4, and concentrated to give the title compound (1.2 g) as a solid which was used in the next step without further purification.

Aufarbeitung

  1. concentrationAfter concentration
  2. extractionextracted with methylene chloride
  3. washThe organic layer was washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-f388d190d9db4f81adbcdec40d8a0a90
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07144881B2

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