1-(2-Chloroethyl)-4-(methylsulfonyl)piperazine → 6-(2-Chloroethyl)-2-oxa-6-azaspiro[3.3]heptane

Reaktionsgleichung

[Cl:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8]N(S(C)(=O)=O)C[CH2:5]1.[CH2:14]1C2(CNC2)[CH2:16][O:15]1>>[Cl:1][CH2:2][CH2:3][N:4]1[CH2:5][C:8]2([CH2:16][O:15][CH2:14]2)[CH2:9]1

Komponenten

Edukt 2

HCID 201583501-(2-Chloroethyl)-4-(methylsulfonyl)piperazine

HCID 231118872-Oxa-6-azaspiro[3.3]heptane

Produkt 1

HCID 682759396-(2-Chloroethyl)-2-oxa-6-azaspiro[3.3]heptane

Versuchsvorschrift

The title compound was prepared following the method described above for the synthesis of 1-(2-chloroethyl)-4-(methylsulfonyl)piperazine using 2-oxa-6-azaspiro[3.3]heptane as the starting reagent. The product was isolated as colorless oil (10 mg, 12%). LCMS: m/e 162.15 (M+H)+, 0.87 min (method 10).

Quellen und Nachweise

ORD-Eintrag: ord-0099398f1d1a4ecea0b0514be075a909
Quelldatensatz: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08846647B2

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