Hydrochloric Acid → 4-(Methanesulfonyl)piperidine

HRID 85731Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 85731
[CH3:1][S:2]([CH:5]1[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1)(=[O:4])=[O:3].Cl>C1COCC1>[CH3:1][S:2]([CH:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:4])=[O:3]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 22504298Tert-butyl 4-(methylsulfonyl)piperidine-1-carboxylate

Produkt 1

HCID 222750384-(Methanesulfonyl)piperidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

A mixture of tert-butyl 4-(methylsulfonyl)piperidine-1-carboxylate (1.5 g, 5.70 mmol) and hydrogen chloride (7.12 mL, 28.5 mmol) in THF (20 mL) was stirred at 20° C. for 15 hours. TLC indicated the formation of desired product, the reaction mixture was filtered and the pale yellow solid was collected to provide desired product (1 g, 88%). LCMS: m/e 163.96 (M+H)+, 0.25 min (method 10).

Quellen und Nachweise

ORD-Eintrag
ord-fe60ead0482c4a67a8aa2f5848de269c
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846647B2

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