Nitric Acid → HCID 178526772, Verbindung

Reaktionsgleichung

[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:12])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[N+:13]([O-])([OH:15])=[O:14]>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:12])=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=[N:9]2)=[CH:4][CH:3]=1

Komponenten

Edukt 2

HCID 944Nitric Acid

HCID 178516426HCID 178516426, Verbindung

Produkt 1

HCID 178526772HCID 178526772, Verbindung

Versuchsvorschrift

7-Chloro-4-hydroxyquinoline (35 g, 0.195 mol; available from Aldrich, Milwaukee, Wis.) and nitric acid (350 mL of 70%) were combined and heated at reflux for 75 minutes. The reaction mixture was poured over ice while still hot. The resulting bright yellow precipitate was isolated by filtration and then washed 3 times with boiling ethyl acetate to provide 17.3 g of 7-chloro-3-nitro-4-hydroxyquinoline as a pale yellow solid.

Aufarbeitung

temperatureheated
temperatureat reflux for 75 minutes
additionThe reaction mixture was poured over ice while still hot
customThe resulting bright yellow precipitate was isolated by filtration
washwashed 3 times with boiling ethyl acetate

Quellen und Nachweise

ORD-Eintrag: ord-fa314b45250d447bb878cc46cd46404a
Quelldatensatz: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07148232B2

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