4-Toluenesulfonyl chloride → 3,3'-Methylenebis[4-tosylcoumarin]

Beteiligte Stoffe

Reaktionsschritte

To a solution of dicumarol (10 mmol) and p-toluenesulfonyl chloride (1.0 eq.) in dichloromethane (20 ml), triethylamine was added at room temperature under air atmosphere. After the reaction was complete, as monitored by TLC, the reaction mixture was evaporated and the residue was purified by flash chromatography (silica gel) to afford the product, 3,3′-methylenebis[4-tosylcoumarin].

Herkunft & Nachweise