HCID 21876061, Verbindung → HCID 21876466, Verbindung

HRID 858548Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 858548
[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]3[CH:18]=[C:19]([Cl:26])[C:20]([C:22]([F:25])([F:24])[F:23])=[CH:21][C:16]=3[N:15]=[C:14]2[C:27]([N:30]=[N+]=[N-])([CH3:29])[CH3:28])=[CH:9][CH:8]=1)(=[O:3])[CH3:2]>[Pd].CC([O-])=O.CC([O-])=O.[Pb+2].CO>[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([N:13]2[C:17]3[CH:18]=[C:19]([Cl:26])[C:20]([C:22]([F:24])([F:25])[F:23])=[CH:21][C:16]=3[N:15]=[C:14]2[C:27]([NH2:30])([CH3:29])[CH3:28])=[CH:11][CH:12]=1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 21876061HCID 21876061, Verbindung

Produkt 1

HCID 21876466HCID 21876466, VerbindungAusbeute 98,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 131709914Lindlars catalystKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 2-{4-[2-(1-azido-1-methylethyl)-6-chloro-5-(trifluoromethyl)-1H-benzimidazol-1-yl]phenyl}ethyl acetate (step 2, 133 mg, 0.28 mmol) and Lindlar catalyst (13 mg) in methanol (5 ml) was stirred under H2 atmosphere at room temperature for 2.5 h. The catalyst was removed by filtration through a pad of celite and the filtrates were concentrated to give the title compound as yellow oil (121 mg, 98%).

Aufarbeitung

  1. customThe catalyst was removed by filtration through a pad of celite
  2. concentrationthe filtrates were concentrated

Quellen und Nachweise

ORD-Eintrag
ord-8b94c676c3524dd0b5a29f39ff6223f5
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07148234B2

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