Benzene, 1-bromo-3-ethyl- → 6-(3-ethylphenethyl)-6-cyclopentyl-dihydro-3H-pyran-2,4-dione

HRID 858882

Reaktionsgleichung

Reaktionsgleichung von HRID 858882
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH3:9])[CH:3]=1.BrC1C=CC(C(C)C)=C(F)C=1.[CH:21]1([C:26]([OH:39])([C:37]#[CH:38])[CH2:27][C:28]2[O:33]C(C)(C)O[C:30](=[O:36])[CH:29]=2)[CH2:25][CH2:24][CH2:23][CH2:22]1>>[CH:21]1([C:26]2([CH2:37][CH2:38][C:2]3[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH3:9])[CH:3]=3)[O:39][C:30](=[O:36])[CH2:29][C:28](=[O:33])[CH2:27]2)[CH2:22][CH2:23][CH2:24][CH2:25]1

Komponenten

4

Edukt 3

HCID 123170Benzene, 1-bromo-3-ethyl-HCID 210510924-Bromo-2-fluoro-1-(1-methylethyl)benzeneHCID 224998026-(2-Cyclopentyl-2-hydroxy-but-3-ynyl)-2,2-dimethyl-[1,3]dioxin-4-one

Produkt 1

HCID 160761086-(3-ethylphenethyl)-6-cyclopentyl-dihydro-3H-pyran-2,4-dione

Versuchsvorschrift

The title compound was prepared analogously to Example A(64), where 1-Bromo-3-ethyl-benzene was substituted in place of 4-bromo-2-fluoro-1-isopropylbenzene in that example, and Enantiomer A of 6-(2-cyclopentyl-2-hydroxybut-3-ynyl)-2,2-dimethyl-4H-1,3-dioxin-4-one was used in place of the racemic alkyne.

Quellen und Nachweise

ORD-Eintrag
ord-0b04e3c1de6247ecbb5d5e7b2e0266b9
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07148226B2

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