HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Piperidineethanol → benzyl N-[4-(2-hydroxyethyl)piperidine-1-carboximidoyl]carbamate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Piperidineethanol | HCID 73953 | — |
| Edukt | Benzyl [amino(methylsulfanyl)methylene]carbamate | HCID 140362141 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | benzyl N-[4-(2-hydroxyethyl)piperidine-1-carboximidoyl]carbamate | HCID 140379078 | 41% |
Reaktionsschritte
A mixture of 6.2 g (0.028 mol) of 4-hydroxyethyl piperidine and 3.6 g (0.028 mol) of N-benzyloxycarbonyl-S-methyl isothiourea in 50 ml of acetonitrile was refluxed overnight. Evaporation and flash chromatography on silica gel with ethyl acetate gave 3.5 g (41%) of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05723444 |
| Quelldatensatz | uspto-grants-1998_03 |
| ORD ID | ord-38cb457f7729445685e412a4fffa8894 |
| Quellennotiz | uspto-grants-1998_03 |