HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Cesium carbonate → (RS)-1-[4-(2-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Cesium carbonate | HCID 10796 | — |
| Edukt | alpha-Bromo-o-fluorotoluene | HCID 67968 | — |
| Edukt | Methyl 1-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylate | HCID 2883518 | — |
| Produkt | (RS)-1-[4-(2-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester | HCID 68615230 | 82% |
Reaktionsschritte
In an analogous manner to that described in Example 13 a), the alkylation of the (RS)-1-(4-hydroxy-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester [Example 2 b)] with 2-fluorobenzyl-bromide using cesium carbonate as the base at RT yields (RS)-1-[4-(2-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester as a light yellow solid (yield 82% of theory).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07151111B2 |
| Quelldatensatz | uspto-grants-2006_12 |
| ORD ID | ord-a400036c7756479fb11582f7de19a92a |
| Quellennotiz | uspto-grants-2006_12 |