HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 86Erstellt: 23. Oktober 2026
4-Bromo-2-nitroanisole → 1-(7-(4-Methoxy-3-nitrophenyl)-9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)ethanone
https://huagongshe.com/de/reaction/86
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 4-Bromo-2-nitroanisole | HCID 118533 | — |
| Edukt | 1-(9-Oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)ethan-1-one | HCID 68592728 | — |
| Reagenz | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Katalysator | 2-(Dicyclohexylphosphino)biphenyl | HCID 2734216 | — |
| Katalysator | Palladium (II) acetate | HCID 4144353 | — |
| Lösungsmittel | 1,2-Dimethoxyethane | HCID 8071 | — |
| Produkt | 1-(7-(4-Methoxy-3-nitrophenyl)-9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)ethanone | HCID 68592987 | 0% |
Reaktionsschritte
1-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)ethanone (36.3 mg, 0.21 mmol), 4-bromo-1-methoxy-2-nitrobenzene (45 mg, 0.19 mmol), diacetoxypalladium (4.35 mg, 0.02 mmol), biphenyl-2-yldicyclohexylphosphine (10.88 mg, 0.03 mmol) and potassium phosphate (61.8 mg, 0.29 mmol) in DME (0.5 mL) were degassed with nitrogen and stirred at 80 °C overnight => _no product formed, degradation_ **_ABANDONED_**
Herkunft & Nachweise
| Quelldatensatz | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-e6979ae841a4470289e0e5d2e2b42616 |
|---|
| Quellennotiz | 750 AstraZeneca ELN dataset |
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