Piperazine → 6-Bromoquipazine

HRID 860009

Reaktionsgleichung

Reaktionsgleichung von HRID 860009
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](Cl)[CH:6]=[CH:5]2.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>CN(C)C=O.C(=O)(O)[O-].[Na+]>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)[CH:6]=[CH:5]2

Komponenten

5

Edukt 2

HCID 4837PiperazineHCID 128940866-Bromo-2-chloroquinoline

Produkt 1

HCID 1302616-Bromoquipazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 516892Sodium BicarbonateLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

To a solution of 6-bromo-2-chloroquinoline of Step A (1.25 g, 5.15 mmol) in N,N-dimethylformamide (35 mL) is added piperazine (4.43 g, 51.4 mmol) and the mixture is heated at 110° C. under nitrogen for 3 hours. After cooling, it is diluted with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The extracts are dried over anhydrous magnesium sulfate and evaporated to dryness.

Aufarbeitung

  1. temperatureAfter cooling
  2. extractionextracted with ethyl acetate
  3. dry with materialThe extracts are dried over anhydrous magnesium sulfate
  4. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-0968b3c8b57a4bc28a0ab591d4bbdb7e
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07153849B2

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