Sodium Hydroxide → n-(4-Carbamimidoyl-phenyl)-2-phenyl-malonamic acid sodium salt

HRID 860178Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 860178
C([O:8][C:9](=[O:29])[CH:10]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:11]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([C:20](=[NH:22])[NH2:21])=[CH:16][CH:15]=1)=[O:12])C1C=CC=CC=1.[OH-].[Na+:31]>C1COCC1>[Na+:31].[C:20]([C:17]1[CH:16]=[CH:15][C:14]([NH:13][C:11](=[O:12])[CH:10]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:9]([O-:29])=[O:8])=[CH:19][CH:18]=1)(=[NH:21])[NH2:22]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 10110753HCID 10110753, Verbindung

Produkt 1

HCID 23700157n-(4-Carbamimidoyl-phenyl)-2-phenyl-malonamic acid sodium salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

8.26 g (19.5 mmol) of the benzyl ester from example 1 were dissolved in 100 ml THF and stirred overnight with 20 ml 2 M aqueous NaOH. The solvent was removed after filtration, water was added, and the solution extracted with diethyl ether. The aqueous phase was freeze dried and sufficiently pure for further derivatization.

Aufarbeitung

  1. customThe solvent was removed
  2. filtrationafter filtration, water
  3. additionwas added
  4. extractionthe solution extracted with diethyl ether
  5. customdried and sufficiently pure for further derivatization

Quellen und Nachweise

ORD-Eintrag
ord-80021ebbbb5a4ec49a4f9333d7dfcb19
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07153876B2

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