3,5-Dichloroaniline → N-(3,5-dichlorophenyl)alanine isobutyl ester

HRID 860319

Reaktionsgleichung

Reaktionsgleichung von HRID 860319
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].[C:10]([O:15][CH2:16][CH:17]([CH3:19])[CH3:18])(=[O:14])[C:11]([CH3:13])=O>>[CH2:16]([O:15][C:10](=[O:14])[C@H:11]([CH3:13])[NH:5][C:4]1[CH:3]=[C:2]([Cl:1])[CH:8]=[C:7]([Cl:9])[CH:6]=1)[CH:17]([CH3:19])[CH3:18]

Komponenten

3

Edukt 2

HCID 122813,5-DichloroanilineHCID 83084Isobutyl pyruvate

Produkt 1

HCID 54461425N-(3,5-dichlorophenyl)alanine isobutyl ester

Versuchsvorschrift

Following General Procedure AA above and using 3,5-dichloroaniline (Aldrich) and iso-butyl pyruvate (prepared by following General Procedure AO above), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

Aufarbeitung

  1. customThe reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification

Quellen und Nachweise

ORD-Eintrag
ord-0c6be54c185c40c9b9b53cbf0a92453f
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07153847B2

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