Venlafaxine → Desvenlafaxine

HRID 860915

Reaktionsgleichung

Reaktionsgleichung von HRID 860915
C(S)CCCCCCCCCCC.[CH3:14][N:15]([CH2:17][CH:18]([C:27]1([OH:33])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)[C:19]1[CH:20]=[CH:21][C:22]([O:25]C)=[CH:23][CH:24]=1)[CH3:16].C([O-])C.[Na+]>>[CH3:14][N:15]([CH2:17][CH:18]([C:27]1([OH:33])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)[C:19]1[CH:20]=[CH:21][C:22]([OH:25])=[CH:23][CH:24]=1)[CH3:16]

Komponenten

4

Edukt 3

HCID 5656VenlafaxineHCID 81951-DodecanethiolHCID 2723922Sodium ethoxide

Produkt 1

HCID 125017Desvenlafaxine

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

Dodecanethiol (69 g), venlafaxine (55 g), and an ethanolic solution of sodium ethanolate (21%, 82 g) are charged to a pressure vessel. The temperature is raised to 150° C. and the reaction mixture is stirred for 2 days. Then the temperature is lowered and the solution is filtered. The pH of the filtrate is adjusted to 9.5 with aqueous hydrogen chloride. The crystals are collected by suction filtration. The cake is washed with ethanol and dried in vacuo.

Aufarbeitung

  1. filtrationthe solution is filtered
  2. filtrationThe crystals are collected by suction filtration
  3. washThe cake is washed with ethanol
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1f210c72ef1d4d6dbed5314b68ac8d0c
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07154001B2

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