Selenium Dioxide → 3-Hydroxy-6-methylpyridine-2-carbaldehyde
Reaktionsgleichung
[OH:1][C:2]1[C:3]([CH2:9][OH:10])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[Se](=O)=O>O1CCOCC1.C(O)C>[OH:1][C:2]1[C:3]([CH:9]=[O:10])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
3-Hydroxy-6-methyl-2-pyridine methanol (20.0 g, 0.14 mol) and selenium dioxide(8.0 g, 72 mmol) were dissolved in 140 mL of 1,4-dioxane and 280 mL of absolute ethanol. The resulting mixture was heated at 80°-85° C. for 12 h. The selenium precipitate was removed by filtration and the filtrate was concentrated to dryness in vacuo. The dark red residue was sublimed at 90° C. and 14 mmHg for 6 h to obtain 11.0 g (56%) of pure product, m.p. 101°-102° C.; 1H NMR (CDCl3) d: 10.50 (br s, 1H), 10.03 (s, 1H), 7.27 (s, 2H); 2.53 (s, 3H).
Aufarbeitung
- temperatureThe resulting mixture was heated at 80°-85° C. for 12 h
- customThe selenium precipitate was removed by filtration
- concentrationthe filtrate was concentrated to dryness in vacuo
- customwas sublimed at 90° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-6b51a0c2361f4838a200fe41f8592ec1
- Quelldatensatz
- uspto-grants-1998_02
- Patentnummer
- US05714615
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