Triphenylphosphine → HCID 178444533, Verbindung

HRID 861760Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 861760
N(C(OCC)=O)=NC(OCC)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[F:32][C:33]1[CH:34]=[C:35]([OH:41])[CH:36]=[C:37]([F:40])[C:38]=1[F:39].[CH2:42]([C@H:47]1[CH2:52][CH2:51][C@H:50]([CH2:53]O)[CH2:49][CH2:48]1)[CH2:43][CH2:44][CH2:45][CH3:46]>O1CCCC1>[CH2:42]([C@H:47]1[CH2:52][CH2:51][C@H:50]([CH2:53][O:41][C:35]2[CH:34]=[C:33]([F:32])[C:38]([F:39])=[C:37]([F:40])[CH:36]=2)[CH2:49][CH2:48]1)[CH2:43][CH2:44][CH2:45][CH3:46]

Komponenten

6

Edukt 4

HCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 27779433,4,5-TrifluorophenolHCID 178444539HCID 178444539, Verbindung

Produkt 1

HCID 178444533HCID 178444533, VerbindungAusbeute 52,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

1.31 g (7.5 mmol) of diethyl azodicarboxylate are added at 0° C. to 1.97 g (7.50 mmol) of triphenylphosphine in 30 ml of tetrahydrofuran, and the mixture is stirred at room temperature for 0.5 hour. 1.11 g (7.50 mmol) of 3,4,5-trifluorophenol and 1.38 g (7.50 mmol) of trans-4-pentylcyclohexylmethanol are then added, and the mixture is stirred at room temperature for 18 hours. Evaporation of the solvent and chromatography on silica gel using hexane give 1.23 g of product. ##STR5## Phase sequence: X 14 (-26) I

Aufarbeitung

  1. stirringthe mixture is stirred at room temperature for 18 hours
  2. customEvaporation of the solvent and chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-8c1e13d2992a47ffa393c16a77725929
Quelldatensatz
uspto-grants-1998_02
Patentnummer
US05716543

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