Ethyl Bromide → 2-Ethoxybenzonitrile

HRID 8620

Reaktionsgleichung

Reaktionsgleichung von HRID 8620
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].[CH2:16](Br)[CH3:17]>CC(C)=O>[CH2:16]([O:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5])[CH3:17]

Komponenten

5

Edukt 3

HCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 119072-Hydroxybenzonitrile

Produkt 1

HCID 5769222-EthoxybenzonitrileAusbeute 97,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

25 g (210 mmol) of 2-hydroxylbenzonitrile are heated, together with 87 g of potassium carbonate and 34.3 g (314.8 mmol) of ethyl bromide, in 500 ml of acetone under reflux overnight. The solid is filtered off, the solvent is removed in vacuo and the residue is distilled in vacuo. 30.0 g (97%) of a colorless liquid are obtained.

Aufarbeitung

  1. temperatureunder reflux overnight
  2. filtrationThe solid is filtered off
  3. customthe solvent is removed in vacuo
  4. distillationthe residue is distilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ce3fd0b48b39417c9f1ac902d61127bf
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07091203B2

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