Potassium Cyanide → Ethyl 5-(cyanomethyl)imidazo[1,2-a]pyridine-2-carboxylate
Reaktionsgleichung
Cl[CH2:2][C:3]1[N:8]2[CH:9]=[C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1.[C-:17]#[N:18].[K+]>CN(C=O)C>[C:17]([CH2:2][C:3]1[N:8]2[CH:9]=[C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1)#[N:18]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
Title material is made by dissolving the title product of Example 5 in DMF and after cooling to 0° C., reacting with KI and KCN. The reaction is stirred for 6 h at 0° C. After warming to room temperature, title compound is obtained by diluting with CHCl3, washing with water, and removing all solvent in vacuo.
Aufarbeitung
- temperatureAfter warming to room temperature
Quellen und Nachweise
- ORD-Eintrag
- ord-a9f32087fa6042738af023682b205495
- Quelldatensatz
- uspto-grants-1998_02
- Patentnummer
- US05716964
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