3-Bromopyridine-2-carbonitrile → 2,4-Dibromophenol

HRID 862099

Reaktionsgleichung

Reaktionsgleichung von HRID 862099
[Br:1]C1C(C#N)=NC=CC=1.C(O/N=C(\C1C=CC=CN=1)/[C:17]1[CH:22]=[C:21]([Br:23])[CH:20]=[CH:19][C:18]=1[OH:24])(C)(C)C.[C:31]([O:35]/[N:36]=[C:37](\[C:46]1[C:51]([Br:52])=[CH:50][CH:49]=[CH:48][N:47]=1)/[C:38]1[CH:43]=[C:42]([Br:44])[CH:41]=[CH:40][C:39]=1[OH:45])([CH3:34])([CH3:33])[CH3:32]>>[C:31]([O:35]/[N:36]=[C:37](\[C:46]1[C:51]([Br:52])=[CH:50][CH:49]=[CH:48][N:47]=1)/[C:38]1[CH:43]=[C:42]([Br:44])[CH:41]=[CH:40][C:39]=1[OH:45])([CH3:34])([CH3:32])[CH3:33].[Br:1][C:17]1[CH:22]=[C:21]([Br:23])[CH:20]=[CH:19][C:18]=1[OH:24]

Komponenten

5

Edukt 3

HCID 8176943-Bromopyridine-2-carbonitrileHCID 1364637264-bromo-2-[(Z)-N-[(2-methylpropan-2-yl)oxy]-C-pyridin-2-ylcarbonimidoyl]phenolHCID 1364638094-bromo-2-[(Z)-C-(3-bromo-2-pyridinyl)-N-[(2-methylpropan-2-yl)oxy]carbonimidoyl]phenol

Produkt 2

HCID 120052,4-DibromophenolHCID 1364638094-bromo-2-[(Z)-C-(3-bromo-2-pyridinyl)-N-[(2-methylpropan-2-yl)oxy]carbonimidoyl]phenol

Versuchsvorschrift

Employing 3-bromo-2-cyanopyridine (5.88 g) in place of 2-cyanopyridine in the production of Compound 75 in Example 9, substantially the same reaction as in Example 9 was conducted to give (Z)-2-(5-bromo-2-hydroxybenzoyl)-3-bromopyridine O-t-butyloxime (3.74 g) (Compound 81) from 2,4-dibromophenol (8.01 g).

Quellen und Nachweise

ORD-Eintrag
ord-4290b8ae37a64ca5a18ac1f2ba8a6b77
Quelldatensatz
uspto-grants-1998_02
Patentnummer
US05716971

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