Phenol → 1-Naphthyloxy proline amide

HRID 862168

Reaktionsgleichung

Reaktionsgleichung von HRID 862168
FC(F)(F)C(O)=O.C([NH:12][C:13](=[O:26])[C@@H:14]1[CH2:18][C@H:17](OC2C=CC=CC=2)[CH2:16][NH:15]1)(C)(C)C.[C:27]1([OH:37])[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][CH:28]=1.C1(O)C=CC=CC=1>>[C:27]1([O:37][N:15]2[CH2:16][CH2:17][CH2:18][C@H:14]2[C:13]([NH2:12])=[O:26])[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][CH:28]=1

Komponenten

4

Edukt 3

HCID 996PhenolHCID 70051-NaphtholHCID 22862000n-t-Butyl-4(s)-phenoxy-l-prolineamide trifluoroacetic acid salt

Produkt 1

HCID 228619921-Naphthyloxy proline amide

Versuchsvorschrift

Following substantially the same procedure for synthesizing N-t-butyl-4(S)-phenoxy-L-prolineamide trifluoroacetic acid salt as outlined in Example 1, Steps 6 through 8, but substituting 1-naphthol for the phenol used therein, the 1-naphthyloxy proline amide was produced.

Quellen und Nachweise

ORD-Eintrag
ord-2df1ec053b4c40c28a1a10757fc5e337
Quelldatensatz
uspto-grants-1998_02
Patentnummer
US05717097

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