Ethanol hydrochloride → 1-(Benzo[b]thiophen-5-yl)-2-[(piperazin-2-yl)methoxy]ethanol dihydrochloride

HRID 862544Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 862544
[ClH:1].C(O)C.[S:5]1[CH:9]=[CH:8][C:7]2[CH:10]=[C:11]([CH:14]([OH:28])[CH2:15][O:16][CH2:17][CH:18]3[CH2:23][N:22](C=O)[CH2:21][CH2:20][N:19]3C=O)[CH:12]=[CH:13][C:6]1=2>CO>[ClH:1].[ClH:1].[S:5]1[CH:9]=[CH:8][C:7]2[CH:10]=[C:11]([CH:14]([OH:28])[CH2:15][O:16][CH2:17][CH:18]3[CH2:23][NH:22][CH2:21][CH2:20][NH:19]3)[CH:12]=[CH:13][C:6]1=2

Komponenten

4

Edukt 2

HCID 21887872Ethanol hydrochlorideHCID 53826975(Benzo[b]thiophen-5-yl)-2-[(1,4-diformylpiperazin-2-yl)methoxy]ethanol

Produkt 1

HCID 675982851-(Benzo[b]thiophen-5-yl)-2-[(piperazin-2-yl)methoxy]ethanol dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

In 1.5 ml of methanol was dissolved 270 mg of -(benzo[b]thiophen-5-yl)-2-[(1,4-diformylpiperazin-2-yl)methoxy]ethanol. To the solution was added 1.5. ml. of a 5N dry hydrogen chloride-ethanol solution. The resulting mixture was allowed to stand at room temperature overnight. The resulting crystals were collected by filtration, washed with ethanol, and dried to obtain 150 mg of 1-(benzo[b]thiophen-5-yl)-2-[(piperazin-2-yl)methoxy]ethanol dihydrochloride (compound No. 355).

Aufarbeitung

  1. additionTo the solution was added 1.5
  2. filtrationThe resulting crystals were collected by filtration
  3. washwashed with ethanol
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-8ed52643e5b446e7bd980fc348aed61e
Quelldatensatz
uspto-grants-1998_02
Patentnummer
US05719150

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