Thionyl Chloride → 4-[(2-methylbenzoyl)amino]benzoyl Chloride

HRID 863006Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 863006
[CH3:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([C:11](O)=[O:12])=[CH:9][CH:8]=1)=[O:5].S(Cl)([Cl:22])=O>>[CH3:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([Cl:22])=[O:12])=[CH:9][CH:8]=1)=[O:5]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 116158144-[(2-methylbenzoyl)amino]benzoic Acid

Produkt 1

HCID 107074414-[(2-methylbenzoyl)amino]benzoyl Chloride

Versuchsvorschrift

A mixture of 10.3 g of 4-[(2-methylbenzoyl)-amino]benzoic acid and 32 ml of thionyl chloride is refluxed for 1.5 hours. The solution is concentrated under vacuum. Toluene is added and the solvent removed under vacuum. Toluene is added and the mixture chilled and filtered to give a yellow solid, m.p. 135°-141° C.

Aufarbeitung

  1. temperatureis refluxed for 1.5 hours
  2. concentrationThe solution is concentrated under vacuum
  3. additionToluene is added
  4. customthe solvent removed under vacuum
  5. additionToluene is added
  6. temperaturethe mixture chilled
  7. filtrationfiltered
  8. customto give a yellow solid, m.p. 135°-141° C.

Quellen und Nachweise

ORD-Eintrag
ord-3d83fe195c6b467cafe01de43fbc7e57
Quelldatensatz
uspto-grants-1998_02
Patentnummer
US05719278

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