Dimethyl Sulfate → N-(7-methoxynaphthalen-1-yl)acetamide

HRID 863505

Reaktionsgleichung

Reaktionsgleichung von HRID 863505
[C:1]([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[CH:13]=[C:12]([OH:15])[CH:11]=[CH:10]2)(=[O:3])[CH3:2].S(OC)(O[CH3:20])(=O)=O.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[CH:13]=[C:12]([O:15][CH3:20])[CH:11]=[CH:10]2)(=[O:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 809461-Acetamido-7-naphthol

Produkt 1

HCID 11447230N-(7-methoxynaphthalen-1-yl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 8-Acetamido-2-naphthol (21 g, 0.104 mol), dimethyl sulfate (15.1 g, 0.12 mol) and potassium carbonate (41 g, 0.3 mol) in acetone (200 mL) was stirred at room temperature for 48 h. Solids were removed by filtration and washed with methanol, and the filtrate evaporated. The residue was washed in 1:1 hexane:toluene, collected by filtration and dried (24.7 g).

Aufarbeitung

  1. customSolids were removed by filtration
  2. washwashed with methanol
  3. customthe filtrate evaporated
  4. washThe residue was washed in 1:1 hexane
  5. filtrationtoluene, collected by filtration
  6. customdried (24.7 g)

Quellen und Nachweise

ORD-Eintrag
ord-6af2e0d4890a4fea8e82f0200997e77e
Quelldatensatz
uspto-grants-1998_02
Patentnummer
US05721234

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