2,3-Dihydro-5-methoxy-6-(phenylmethoxy)-2-(phenylmethyl)-1H-isoindole → 2,3-dihydro-6-methoxy-1H-isoindol-5-ol

HRID 863908

Reaktionsgleichung

Reaktionsgleichung von HRID 863908
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH2:13]C1C=CC=CC=1)[CH2:8][N:7](CC1C=CC=CC=1)[CH2:6]2>[OH-].[OH-].[Pd+2].C(O)C>[CH3:13][O:12][C:11]1[CH:10]=[C:9]2[C:5]([CH2:6][NH:7][CH2:8]2)=[CH:4][C:3]=1[OH:2]

Komponenten

4

Edukt 1

HCID 107363032,3-Dihydro-5-methoxy-6-(phenylmethoxy)-2-(phenylmethyl)-1H-isoindole

Produkt 1

HCID 102411352,3-dihydro-6-methoxy-1H-isoindol-5-olAusbeute 87,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To 35 mL of ethyl alcohol is added 0.5 g of 2,3-dihydro-5-methoxy-6-(phenylmethoxy)-2-(phenylmethyl)-1H-isoindole. The solution is warmed until everything is dissolved. The solution is cooled to room temperature and 0.13 g of 35% palladium hydroxide on carbon is added. The resulting mixture is shaken on a Parr apparatus at 50 pounds per square inch for 21 hours. The solution is filtered through a pad of diatomaceous earth and the pad washed with ethyl alcohol. The volatiles are removed to afford 0.209 g of the desired product as a tan solid.

Aufarbeitung

  1. temperatureThe solution is warmed until everything
  2. dissolutionis dissolved
  3. filtrationThe solution is filtered through a pad of diatomaceous earth
  4. washthe pad washed with ethyl alcohol
  5. customThe volatiles are removed

Quellen und Nachweise

ORD-Eintrag
ord-888796b656fa43f49d687edd5038dc64
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05561141

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