3-Thieno[2,3-d]isoxazol-3-yl-phenol → (3-Fluoro-benzyl)-[2-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-amine

HRID 8640

Reaktionsgleichung

Reaktionsgleichung von HRID 8640
C(OC([N:8]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=1)[CH2:9][CH2:10][O:11]S(C1C=CC(C)=CC=1)(=O)=O)=O)(C)(C)C.[O:30]1[C:34]2[CH:35]=[CH:36][S:37][C:33]=2[C:32]([C:38]2[CH:39]=[C:40](O)[CH:41]=[CH:42][CH:43]=2)=[N:31]1>>[F:29][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][CH:26]=1)[CH2:22][NH:8][CH2:9][CH2:10][O:11][C:42]1[CH:41]=[CH:40][CH:39]=[C:38]([C:32]2[C:33]3[S:37][CH:36]=[CH:35][C:34]=3[O:30][N:31]=2)[CH:43]=1

Komponenten

3

Edukt 2

HCID 140972423-Thieno[2,3-d]isoxazol-3-yl-phenolHCID 23548235Toluene-4-sulfonic acid 2-[tert-butoxycarbonyl-(3-fluoro-benzyl)-amino]-ethyl ester

Produkt 1

HCID 9907296(3-Fluoro-benzyl)-[2-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-amine

Versuchsvorschrift

The title compound is prepared from a mixture of toluene-4-sulfonic acid 2-[tert-butoxycarbonyl-(3-fluoro-benzyl)-amino]-ethyl ester and 3-thieno[2,3-d]isoxazol-3-yl-phenol essentially as described in Example 3, Scheme I, Step F. It is understood by one skilled in the art that the nitrogen may be deprotected by acid hydrolysis, to give the final, desired compound.

Aufarbeitung

  1. custommay be deprotected by acid hydrolysis

Quellen und Nachweise

ORD-Eintrag
ord-1dd22aeb2ee24793a8ccc69ebe25774c
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07091199B1

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