Potassium Hydroxide → 5-bromo-6-methoxy-1H-indole-2-carboxylic acid

HRID 864415Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 864415
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[NH:7][C:6]([C:13]([O:15]C)=[O:14])=[CH:5]2.[OH-].[K+]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[NH:7][C:6]([C:13]([OH:15])=[O:14])=[CH:5]2

Komponenten

3

Edukt 2

HCID 14797Potassium HydroxideHCID 16726758methyl 5-bromo-6-methoxy-1H-indole-2-carboxylate

Produkt 1

HCID 194188695-bromo-6-methoxy-1H-indole-2-carboxylic acid

Versuchsvorschrift

Following the general procedure of PREPARATION 63 and making non-critical variations but starting with methyl 5-bromo-6-methoxyindole carboxylate (PREPARATION 81, 3.31 g) and potassium hydroxide (0.98 g), the title compound is obtained, NMR (300 MHz, CD3OD) 7.79, 7.03, 7.01 and 3.89 δ.

Aufarbeitung

  1. customthe general procedure of PREPARATION 63

Quellen und Nachweise

ORD-Eintrag
ord-62808255a3494311863925c11acc816f
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05563142

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