Potassium Hydroxide → 6-(dimethylamino)-1H-indole-2-carboxylic acid

HRID 864419Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 864419
[CH3:1][N:2]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[C:9]([C:13]([O:15]C)=[O:14])[NH:10]2)=[CH:6][CH:5]=1)[CH3:3].[OH-].[K+]>>[CH3:3][N:2]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[C:9]([C:13]([OH:15])=[O:14])[NH:10]2)=[CH:6][CH:5]=1)[CH3:1]

Komponenten

3

Edukt 2

HCID 14797Potassium HydroxideHCID 4715276methyl 6-(dimethylamino)-1H-indole-2-carboxylate

Produkt 1

HCID 51599086-(dimethylamino)-1H-indole-2-carboxylic acid

Versuchsvorschrift

Following the general procedure of PREPARATION 63 and making non-critical variations but starting with methyl 6-(N,N-dimethylamino)indole-2-carboxylate (PREPARATION 88, 0.80 g), potassium hydroxide (0.25 g), the title compound is obtained, NMR (300 MHz, CD3OD) 7.62, 7.13, 7.11, 7.01, and 3.11 δ.

Aufarbeitung

  1. customthe general procedure of PREPARATION 63

Quellen und Nachweise

ORD-Eintrag
ord-351f068d2c5e4e2981f62b7c7d8a2302
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05563142

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