Methyl iodide → Methyl 2-amino-6-chlorobenzoate

HRID 864715

Reaktionsgleichung

Reaktionsgleichung von HRID 864715
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([NH2:11])[C:7]=1[C:8]([OH:10])=[O:9].I[CH3:13].[OH-].[K+]>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([NH2:11])[C:7]=1[C:8]([O:10][CH3:13])=[O:9]

Komponenten

4

Edukt 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 750712-Amino-6-chlorobenzoic acid

Produkt 1

HCID 592849Methyl 2-amino-6-chlorobenzoateAusbeute 78,4 %

Versuchsvorschrift

Using the procedure described above in Preparation 1, 5.0 g (0.029 mol) of 6-chloroanthranilic acid and 2.75 ml (0.044 mol) of iodomethane were reacted in the presence of 4.08 g (0.073 mol) of powdered potassium hydroxide to give 4.22 g (78%) of methyl 6-chloroanthranilate as an oil.

Quellen und Nachweise

ORD-Eintrag
ord-8cd00d734c5444f1804c2288e1aabf23
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05563163

Verknüpfte Notizen

Wird geladen…