1,3-Diphthalimido-2-propanol → HCID 23374871, Verbindung

HRID 864890Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 864890
[C:1]1(=[O:26])[N:5]([CH2:6][CH:7](O)[CH2:8][N:9]2[C:13](=[O:14])[C:12]3=[CH:15][CH:16]=[CH:17][CH:18]=[C:11]3[C:10]2=[O:19])[C:4](=[O:21])[C:3]2=[CH:22][CH:23]=[CH:24][CH:25]=[C:2]12.CC(C)=[O:29].OS(O)(=O)=O.O=[Cr](=O)=O>CC(C)=O>[C:1]1(=[O:26])[N:5]([CH2:6][CH2:7][C:8]([N:9]2[C:13](=[O:14])[C:12]3=[CH:15][CH:16]=[CH:17][CH:18]=[C:11]3[C:10]2=[O:19])=[O:29])[C:4](=[O:21])[C:3]2=[CH:22][CH:23]=[CH:24][CH:25]=[C:2]12

Komponenten

4

Edukt 2

HCID 971301,3-Diphthalimido-2-propanolHCID 131709961Jones' reagent

Produkt 1

HCID 23374871HCID 23374871, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a solution of 1,3-diphthalimido-2-hydroxypropane (1.00 g., 2,86 mmol) in 80 mL of acetone was added Jones reagent (chromium trioxide and sulfuric acid) until an orange color persisted. The excess oxidant was removed by the addition of 2-isopropanol until a green color was obtained and the solvents were evaporated under reduced pressure. The residue was partitioned between methylene chloride and water and the layers were separated. The organic layer was washed with water, dried over anhydrous sodium sulfate and evaporated under reduced pressure to give 1,3-diphthalimido-3-oxopropane.

Aufarbeitung

  1. customThe excess oxidant was removed by the addition of 2-isopropanol until a green color
  2. customwas obtained
  3. customthe solvents were evaporated under reduced pressure
  4. customThe residue was partitioned between methylene chloride and water
  5. customthe layers were separated
  6. washThe organic layer was washed with water
  7. dry with materialdried over anhydrous sodium sulfate
  8. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-59981879cec74d92b1b8b10cc3648c47
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05565184

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