Potassium Carbonate → 3-(3-{3-[4-(2-Fluoro-phenyl)-piperazin-1-yl]-propoxy}-phenyl)-thieno[2,3-d]isoxazole

HRID 8654

Reaktionsgleichung

Reaktionsgleichung von HRID 8654
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12]2[C:16]3[S:17][CH:18]=[CH:19][C:15]=3[O:14][N:13]=2)[CH:9]=[CH:10][CH:11]=1.ClCCCOC1C=C(C2C3SC=CC=3ON=2)C=CC=1.[F:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=1[N:46]1[CH2:51][CH2:50][NH:49][CH2:48][CH2:47]1.C(=O)([O-])[O-].[K+].[K+]>>[F:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=1[N:46]1[CH2:51][CH2:50][N:49]([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:7]=[C:8]([C:12]3[C:16]4[S:17][CH:18]=[CH:19][C:15]=4[O:14][N:13]=3)[CH:9]=[CH:10][CH:11]=2)[CH2:48][CH2:47]1

Komponenten

5

Edukt 4

HCID 11430Potassium CarbonateHCID 705291-(2-Fluorophenyl)piperazineHCID 219835563-[3-(3-Chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazoleHCID 219835593-[3-(3-Bromo-propoxy)phenyl]-thieno[2,3-d]isoxazole

Produkt 1

HCID 219835653-(3-{3-[4-(2-Fluoro-phenyl)-piperazin-1-yl]-propoxy}-phenyl)-thieno[2,3-d]isoxazoleAusbeute 100 %

Versuchsvorschrift

The title compound is prepared from a mixture of 3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 1-(2-fluorophenyl) piperazine and potassium carbonate essentially as described above in example 4 except that the column is eluted with a mixture of dichloromethane:methanol (98:2). Combine the appropriate fractions and concentrate to give the title compound (0.45 g, 100% Yield) as a solid. Purity by LC/MS (APCI)=100% area, [M+H]+=438 m/e.

Aufarbeitung

  1. washis eluted with a mixture of dichloromethane:methanol (98:2)
  2. concentrationCombine the appropriate fractions and concentrate

Quellen und Nachweise

ORD-Eintrag
ord-cba101c4b95b4347a538db4ed690cbcd
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07091199B1

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