Dicyclohexylcarbodiimide → L-Proline, 4,4-dimethoxy-
Reaktionsgleichung
C[O:2][C:3](=[O:13])[C@@H:4]1[CH2:8][C:7]([O:11][CH3:12])([O:9][CH3:10])[CH2:6][NH:5]1.N1NN=NC=1C1C=CC=CC=1C1C=CC2N(C(CCCCCC)C(O)=O)C=NC=2C=1.OC1C2N=NNC=2C=CC=1.C1(N=C=NC2CCCCC2)CCCCC1>>[CH3:10][O:9][C:7]1([O:11][CH3:12])[CH2:6][NH:5][C@H:4]([C:3]([OH:13])=[O:2])[CH2:8]1Komponenten
5
Versuchsvorschrift
4,4-Dimethoxy-L-proline methyl ester (1.35 moles, 0.257 g) and 2-[5-[2-(2H-tetrazol-5-yl)phenyl]-1H-benzimidazol-1-yl]octanoic acid (1.23 moles, 0.5 g) were reacted in the presence of hydroxybenzotriazole and dicyclohexylcarbodiimide as in Example 15 to yield 0.220 g of 1-[1-oxo-2-[5-2-(2H-tetrazol-5-yl)phenyl]-1H-benzimidazol-1-yl]octyl]-4,4-dimethoxy-L-proline. (MS).